bernate.pages.dev

Terrence m tumpey biography

    •

Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus

References

  1. Johnson, N. P. & Mueller, J. Updating the accounts: global mortality of the 1918–1920 ‘Spanish’ influenza pandemic. Bull. Hist. Med.76, 105–115 (2002)

    Article Google Scholar

  2. Taubenberger, J. K. & Morens, D. M. 1918 influenza: the mother of all pandemics. Emerg. Infect. Dis.12, 15–22 (2006)

    Article Google Scholar

  3. Tumpey, T. M. et al. Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science310, 77–80 (2005)

    ArticleADSCAS Google Scholar

  4. Kobasa, D. et al. Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus. Nature431, 703–707 (2004)

    ArticleADSCAS Google Scholar

  5. Kash, J. C. et al. Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus. J. Virol.78, 9499–9511 (2004)

    ArticleCAS Google Scholar

  6. Tumpey, T. M. et al. Pathogenicity of inf

      •

    Reconstruction of the 1918 pandemic influenza virus: how revealing the molecular secrets of the virus responsible for the worst pandemic in recorded history can guide our response to future influenza pandemics

    There is an ever-present threat that a pandemic will result from the emergence of a new influenza strain to which humans have little immunity. In 1957 and 1968, new influenza viruses emerged into the human population and spread globally. Those pandemics were associated with high rates of illness and mortality, but both paled in comparison with the influenza pandemic of 1918. Reconstruction of the 1918 pandemic virus and studies to elucidate the exceptional virulence of the virus will be important steps toward understanding virulent influenza strains. One approach has been to reconstruct recombinant viruses, in which genes of the 1918 virus are replaced with genes from contemporary human influenza viruses in attempts to understand which of the eight virus gene segments contribute to its high virulence. The identification of the precise pandemic virus genes associated with

      •

    File:EM of influenza virus.jpg

    DescriptionEM of influenza virus.jpg
    English: This negative stained transmission electron micrograph (TEM) shows recreated 1918 influenza virions that were collected from supernatants of 1918-infected Madin-Darby Canine Kidney (MDCK) cells cultures 18 hours after infection.

    To separate these virions, the MDCK cells are spun down (centrifugation), and the 1918 virus in the fluid is immediately fixed for negative staining. The solid mass in lower center contains MDCK cell debris that did not spin down during the procedure.

    Dr. Terrence Tumpey, one of the organization’s staff microbiologists and a member of the National Center for Infectious Diseases (NCID), recreated the 1918 influenza virus in order to identify the characteristics that made this organism such a deadly pathogen. Research efforts such as this, enables researchers to develop new vaccines and treatments for future pandemic influenza viruses.

    The 1918 Spanish flu epidemic was caused by an influenza A (H1N1) virus, killing more than 500,000 people in the United States, and up to

Copyright ©bernate.pages.dev 2025